Gene therapy with adeno-associated virus (AAV)-based vectors shows great promise for the gene therapeutic treatment of a broad array of diseases.In fact, the treatment of genetic diseases with AAV vectors is currently the only in vivo gene therapy approach that is approved by the US Food and Drug Administration (FDA).Unfortunately, pre-existing ant
The death of massive stars, Facial manifested as gamma-ray bursts and core-collapse supernovae, critically influence how the universe formed and evolves.Despite their fundamental importance, our understanding of these enigmatic objects is severely limited.We have performed a concept study of an Astrophysical Transient Observatory (ATO) that will ra
The Venice Charter (1964) meant -50 years ago- an important step for the worldwide application of normative principles as for theory and the practice of the architectural restoration.The objective of this article is to present and to recognize, fifty years after its promulgation, the importance and the influence of the Venice Charter in the theory
We propose an efficient scheme for side peaks cancelation and multipath (MP) mitigation in binary offset copyright (n,n) (BOC(n,n)) and multiplexed BOC (MBOC) modulated signals.The proposed scheme reduces significantly the band of variation of MP errors in global navigation satellite system (GNSS).It consists of two versions.The first one is based